DRUG-RECEPTOR RECOGNITION: MOLECULAR ORIENTATION AND DIELECTRIC EFFECTS
نویسندگان
چکیده
منابع مشابه
Molecular determinants of drug-receptor binding kinetics.
It is increasingly appreciated that the rates at which drugs associate with and dissociate from receptors--the binding kinetics--directly impact drug efficacy and safety. The molecular determinants of drug-receptor binding kinetics remain poorly understood, however, especially when compared with the well-known factors that affect binding affinity. The rational modulation of kinetics during lead...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1981
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1981.tb09954.x